LOCUS NC_002077 4718 bp DNA linear VRL 11-MAR-2010 DEFINITION Adeno-associated virus - 1, complete genome. ACCESSION NC_002077 VERSION NC_002077.1 DBSOURCE BioProject accession PRJNA15323 KEYWORDS RefSeq. SOURCE Adeno-associated virus - 1 ORGANISM Adeno-associated virus - 1 Viruses; ssDNA viruses; Parvoviridae; Parvovirinae; Dependoparvovirus. REFERENCE 1 (bases 1 to 4718) AUTHORS Xiao,W., Chirmule,N., Berta,S.C., McCullough,B., Gao,G. and Wilson,J.M. TITLE Gene therapy vectors based on adeno-associated virus type 1 JOURNAL J. Virol. 73 (5), 3994-4003 (1999) PUBMED 10196295 REFERENCE 2 (bases 1 to 4718) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2000) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 4718) AUTHORS Xiao,W. and Wilson,J.M. TITLE Direct Submission JOURNAL Submitted (05-MAY-1998) IHGT, University of Pennsylvania, 3601 Spruce Street, Philadelphia, PA 19104, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AF063497. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..4718 /mol_type="genomic DNA" /db_xref="taxon:85106" /organism="Adeno-associated virus - 1" /note="AAV1" gene 335..2206 /locus_tag="AAV1gp1" /db_xref="GeneID:1450375" CDS 335..2206 /locus_tag="AAV1gp1" /db_xref="GeneID:1450375" /codon_start=1 /protein_id="NP_049541.1" /translation="MPGFYEIVIKVPSDLDEHLPGISDSFVSWVAEKEWELPPDSDMD LNLIEQAPLTVAEKLQRDFLVQWRRVSKAPEALFFVQFEKGESYFHLHILVETTGVKS MVLGRFLSQIRDKLVQTIYRGIEPTLPNWFAVTKTRNGAGGGNKVVDECYIPNYLLPK TQPELQWAWTNMEEYISACLNLAERKRLVAQHLTHVSQTQEQNKENLNPNSDAPVIRS KTSARYMELVGWLVDRGITSEKQWIQEDQASYISFNAASNSRSQIKAALDNAGKIMAL TKSAPDYLVGPAPPADIKTNRIYRILELNGYEPAYAGSVFLGWAQKRFGKRNTIWLFG PATTGKTNIAEAIAHAVPFYGCVNWTNENFPFNDCVDKMVIWWEEGKMTAKVVESAKA ILGGSKVRVDQKCKSSAQIDPTPVIVTSNTNMCAVIDGNSTTFEHQQPLQDRMFKFEL TRRLEHDFGKVTKQEVKEFFRWAQDHVTEVAHEFYVRKGGANKRPAPDDADKSEPKRA CPSVADPSTSDAEGAPVDFADRYQNKCSRHAGMLQMLFPCKTCERMNQNFNICFTHGT RDCSECFPGVSESQPVVRKRTYRKLCAIHHLLGRAPEIACSACDLVNVDLDDCVSEQ" /product="nonstructural protein" gene 2223..4433 /locus_tag="AAV1gp2" /db_xref="GeneID:1450374" CDS 2223..4433 /locus_tag="AAV1gp2" /db_xref="GeneID:1450374" /codon_start=1 /protein_id="NP_049542.1" /translation="MAADGYLPDWLEDNLSEGIREWWDLKPGAPKPKANQQKQDDGRG LVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLKAGDNPYLRYNHADAEFQE RLQEDTSFGGNLGRAVFQAKKRVLEPLGLVEEGAKTAPGKKRPVEQSPQEPDSSSGIG KTGQQPAKKRLNFGQTGDSESVPDPQPLGEPPATPAAVGPTTMASGGGAPMADNNEGA DGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSASTGASNDNHYFGY STPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTTNDGVTTIA NNLTSTVQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQAVGRSS FYCLEYFPSQMLRTGNNFTFSYTFEEVPFHSSYAHSQSLDRLMNPLIDQYLYYLNRTQ NQSGSAQNKDLLFSRGSPAGMSVQPKNWLPGPCYRQQRVSKTKTDNNNSNFTWTGASK YNLNGRESIINPGTAMASHKDDEDKFFPMSGVMIFGKESAGASNTALDNVMITDEEEI KATNPVATERFGTVAVNFQSSSTDPATGDVHAMGALPGMVWQDRDVYLQGPIWAKIPH TDGHFHPSPLMGGFGLKNPPPQILIKNTPVPANPPAEFSATKFASFITQYSTGQVSVE IEWELQKENSKRWNPEVQYTSNYAKSANVDFTVDNNGLYTEPRPIGTRYLTRPL" /product="capsid protein" ORIGIN 1 ttgcccactc cctctctgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc 61 agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcag agagggagtg 121 ggcaactcca tcactagggg taatcgcgaa gcgcctccca cgctgccgcg tcagcgctga 181 cgtaaattac gtcatagggg agtggtcctg tattagctgt cacgtgagtg cttttgcgac 241 attttgcgac accacgtggc catttagggt atatatggcc gagtgagcga gcaggatctc 301 cattttgacc gcgaaatttg aacgagcagc agccatgccg ggcttctacg agatcgtgat 361 caaggtgccg agcgacctgg acgagcacct gccgggcatt tctgactcgt ttgtgagctg 421 ggtggccgag aaggaatggg agctgccccc ggattctgac atggatctga atctgattga 481 gcaggcaccc ctgaccgtgg ccgagaagct gcagcgcgac ttcctggtcc aatggcgccg 541 cgtgagtaag gccccggagg ccctcttctt tgttcagttc gagaagggcg agtcctactt 601 ccacctccat attctggtgg agaccacggg ggtcaaatcc atggtgctgg gccgcttcct 661 gagtcagatt agggacaagc tggtgcagac catctaccgc gggatcgagc cgaccctgcc 721 caactggttc gcggtgacca agacgcgtaa tggcgccgga ggggggaaca aggtggtgga 781 cgagtgctac atccccaact acctcctgcc caagactcag cccgagctgc agtgggcgtg 841 gactaacatg gaggagtata taagcgcctg tttgaacctg gccgagcgca aacggctcgt 901 ggcgcagcac ctgacccacg tcagccagac ccaggagcag aacaaggaga atctgaaccc 961 caattctgac gcgcctgtca tccggtcaaa aacctccgcg cgctacatgg agctggtcgg 1021 gtggctggtg gaccggggca tcacctccga gaagcagtgg atccaggagg accaggcctc 1081 gtacatctcc ttcaacgccg cttccaactc gcggtcccag atcaaggccg ctctggacaa 1141 tgccggcaag atcatggcgc tgaccaaatc cgcgcccgac tacctggtag gccccgctcc 1201 gcccgcggac attaaaacca accgcatcta ccgcatcctg gagctgaacg gctacgaacc 1261 tgcctacgcc ggctccgtct ttctcggctg ggcccagaaa aggttcggga agcgcaacac 1321 catctggctg tttgggccgg ccaccacggg caagaccaac atcgcggaag ccatcgccca 1381 cgccgtgccc ttctacggct gcgtcaactg gaccaatgag aactttccct tcaatgattg 1441 cgtcgacaag atggtgatct ggtgggagga gggcaagatg acggccaagg tcgtggagtc 1501 cgccaaggcc attctcggcg gcagcaaggt gcgcgtggac caaaagtgca agtcgtccgc 1561 ccagatcgac cccacccccg tgatcgtcac ctccaacacc aacatgtgcg ccgtgattga 1621 cgggaacagc accaccttcg agcaccagca gccgttgcag gaccggatgt tcaaatttga 1681 actcacccgc cgtctggagc atgactttgg caaggtgaca aagcaggaag tcaaagagtt 1741 cttccgctgg gcgcaggatc acgtgaccga ggtggcgcat gagttctacg tcagaaaggg 1801 tggagccaac aaaagacccg cccccgatga cgcggataaa agcgagccca agcgggcctg 1861 cccctcagtc gcggatccat cgacgtcaga cgcggaagga gctccggtgg actttgccga 1921 caggtaccaa aacaaatgtt ctcgtcacgc gggcatgctt cagatgctgt ttccctgcaa 1981 gacatgcgag agaatgaatc agaatttcaa catttgcttc acgcacggga cgagagactg 2041 ttcagagtgc ttccccggcg tgtcagaatc tcaaccggtc gtcagaaaga ggacgtatcg 2101 gaaactctgt gccattcatc atctgctggg gcgggctccc gagattgctt gctcggcctg 2161 cgatctggtc aacgtggacc tggatgactg tgtttctgag caataaatga cttaaaccag 2221 gtatggctgc cgatggttat cttccagatt ggctcgagga caacctctct gagggcattc 2281 gcgagtggtg ggacttgaaa cctggagccc cgaagcccaa agccaaccag caaaagcagg 2341 acgacggccg gggtctggtg cttcctggct acaagtacct cggacccttc aacggactcg 2401 acaaggggga gcccgtcaac gcggcggacg cagcggccct cgagcacgac aaggcctacg 2461 accagcagct caaagcgggt gacaatccgt acctgcggta taaccacgcc gacgccgagt 2521 ttcaggagcg tctgcaagaa gatacgtctt ttgggggcaa cctcgggcga gcagtcttcc 2581 aggccaagaa gcgggttctc gaacctctcg gtctggttga ggaaggcgct aagacggctc 2641 ctggaaagaa acgtccggta gagcagtcgc cacaagagcc agactcctcc tcgggcatcg 2701 gcaagacagg ccagcagccc gctaaaaaga gactcaattt tggtcagact ggcgactcag 2761 agtcagtccc cgatccacaa cctctcggag aacctccagc aacccccgct gctgtgggac 2821 ctactacaat ggcttcaggc ggtggcgcac caatggcaga caataacgaa ggcgccgacg 2881 gagtgggtaa tgcctcagga aattggcatt gcgattccac atggctgggc gacagagtca 2941 tcaccaccag cacccgcacc tgggccttgc ccacctacaa taaccacctc tacaagcaaa 3001 tctccagtgc ttcaacgggg gccagcaacg acaaccacta cttcggctac agcaccccct 3061 gggggtattt tgatttcaac agattccact gccacttttc accacgtgac tggcagcgac 3121 tcatcaacaa caattgggga ttccggccca agagactcaa cttcaaactc ttcaacatcc 3181 aagtcaagga ggtcacgacg aatgatggcg tcacaaccat cgctaataac cttaccagca 3241 cggttcaagt cttctcggac tcggagtacc agcttccgta cgtcctcggc tctgcgcacc 3301 agggctgcct ccctccgttc ccggcggacg tgttcatgat tccgcaatac ggctacctga 3361 cgctcaacaa tggcagccaa gccgtgggac gttcatcctt ttactgcctg gaatatttcc 3421 cttctcagat gctgagaacg ggcaacaact ttaccttcag ctacaccttt gaggaagtgc 3481 ctttccacag cagctacgcg cacagccaga gcctggaccg gctgatgaat cctctcatcg 3541 accaatacct gtattacctg aacagaactc aaaatcagtc cggaagtgcc caaaacaagg 3601 acttgctgtt tagccgtggg tctccagctg gcatgtctgt tcagcccaaa aactggctac 3661 ctggaccctg ttatcggcag cagcgcgttt ctaaaacaaa aacagacaac aacaacagca 3721 attttacctg gactggtgct tcaaaatata acctcaatgg gcgtgaatcc atcatcaacc 3781 ctggcactgc tatggcctca cacaaagacg acgaagacaa gttctttccc atgagcggtg 3841 tcatgatttt tggaaaagag agcgccggag cttcaaacac tgcattggac aatgtcatga 3901 ttacagacga agaggaaatt aaagccacta accctgtggc caccgaaaga tttgggaccg 3961 tggcagtcaa tttccagagc agcagcacag accctgcgac cggagatgtg catgctatgg 4021 gagcattacc tggcatggtg tggcaagata gagacgtgta cctgcagggt cccatttggg 4081 ccaaaattcc tcacacagat ggacactttc acccgtctcc tcttatgggc ggctttggac 4141 tcaagaaccc gcctcctcag atcctcatca aaaacacgcc tgttcctgcg aatcctccgg 4201 cggagttttc agctacaaag tttgcttcat tcatcaccca atactccaca ggacaagtga 4261 gtgtggaaat tgaatgggag ctgcagaaag aaaacagcaa gcgctggaat cccgaagtgc 4321 agtacacatc caattatgca aaatctgcca acgttgattt tactgtggac aacaatggac 4381 tttatactga gcctcgcccc attggcaccc gttaccttac ccgtcccctg taattacgtg 4441 ttaatcaata aaccggttga ttcgtttcag ttgaactttg gtctcctgtc cttcttatct 4501 tatcggttac catggttata gcttacacat taactgcttg gttgcgcttc gcgataaaag 4561 acttacgtca tcgggttacc cctagtgatg gagttgccca ctccctctct gcgcgctcgc 4621 tcgctcggtg gggcctgcgg accaaaggtc cgcagacggc agagctctgc tctgccggcc 4681 ccaccgagcg agcgagcgcg cagagaggga gtgggcaa //