LOCUS NC_006260 4721 bp DNA linear VRL 11-MAR-2010 DEFINITION Adeno-associated virus - 7, complete genome. ACCESSION NC_006260 VERSION NC_006260.1 DBSOURCE BioProject accession PRJNA14454 KEYWORDS RefSeq. SOURCE Adeno-associated virus - 7 ORGANISM Adeno-associated virus - 7 Viruses; ssDNA viruses; Parvoviridae; Parvovirinae; Dependoparvovirus. REFERENCE 1 (bases 1 to 4721) AUTHORS Gao,G.P., Alvira,M.R., Wang,L., Calcedo,R., Johnston,J. and Wilson,J.M. TITLE Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (18), 11854-11859 (2002) PUBMED 12192090 REFERENCE 2 (bases 1 to 4721) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (09-SEP-2004) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 4721) AUTHORS Alvira,M.R. TITLE Direct Submission JOURNAL Submitted (20-MAY-2002) Institute for Human Gene Therapy, University of Pennsylvania, M6.40 Maloney Bldg, 36th & Spruce Sts, Philadelphia, PA 19104, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AF513851. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..4721 /mol_type="genomic DNA" /db_xref="taxon:202812" /proviral /organism="Adeno-associated virus - 7" /host="rhesus monkey" gene 334..2205 /locus_tag="AAV7_gp1" /db_xref="GeneID:5075988" CDS 334..2205 /locus_tag="AAV7_gp1" /db_xref="GeneID:5075988" /codon_start=1 /protein_id="YP_077177.1" /translation="MPGFYEIVIKVPSDLDEHLPGISDSFVNWVAEKEWELPPDSDMD LNLIEQAPLTVAEKLQRDFLVQWRRVSKAPEALFFVQFEKGESYFHLHVLVETTGVKS MVLGRFLSQIREKLVQTIYRGVEPTLPNWFAVTKTRNGAGGGNKVVDECYIPNYLLPK TQPELQWAWTNMEEYISACLNLAERKRLVAQHLTHVSQTQEQNKENLNPNSDAPVIRS KTSARYMELVGWLVDRGITSEKQWIQEDQASYISFNAASNSRSQIKAALDNAGKIMAL TKSAPDYLVGPSLPADIKTNRIYRILELNGYDPAYAGSVFLGWAQKKFGKRNTIWLFG PATTGKTNIAEAIAHAVPFYGCVNWTNENFPFNDCVDKMVIWWEEGKMTAKVVESAKA ILGGSKVRVDQKCKSSAQIDPTPVIVTSNTNMCAVIDGNSTTFEHQQPLQDRMFKFEL TRRLEHDFGKVTKQEVKEFFRWASDHVTEVAHEFYVRKGGASKRPAPDDADISEPKRA CPSVADPSTSDAEGAPVDFADRYQNKCSRHAGMIQMLFPCKTCERMNQNFNICFTHGV RDCLECFPGVSESQPVVRKKTYRKLCAIHHLLGRAPEIACSACDLVNVDLDDCVSEQ" /product="nonstructural protein" /note="similar to AAV2 Rep 78 protein" gene 2222..4435 /locus_tag="AAV7_gp2" /db_xref="GeneID:5075989" CDS 2222..4435 /locus_tag="AAV7_gp2" /db_xref="GeneID:5075989" /codon_start=1 /protein_id="YP_077178.1" /translation="MAADGYLPDWLEDNLSEGIREWWDLKPGAPKPKANQQKQDNGRG LVLPGYKYLGPFNGLDKGEPVNAADAAALEHDKAYDQQLKAGDNPYLRYNHADAEFQE RLQEDTSFGGNLGRAVFQAKKRVLEPLGLVEEGAKTAPAKKRPVEPSPQRSPDSSTGI GKKGQQPARKRLNFGQTGDSESVPDPQPLGEPPAAPSSVGSGTVAAGGGAPMADNNEG ADGVGNASGNWHCDSTWLGDRVITTSTRTWALPTYNNHLYKQISSETAGSTNDNTYFG YSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKKLRFKLFNIQVKEVTTNDGVTTI ANNLTSTIQVFSDSEYQLPYVLGSAHQGCLPPFPADVFMIPQYGYLTLNNGSQSVGRS SFYCLEYFPSQMLRTGNNFEFSYSFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLART QSNPGGTAGNRELQFYQGGPSTMAEQAKNWLPGPCFRQQRVSKTLDQNNNSNFAWTGA TKYHLNGRNSLVNPGVAMATHKDDEDRFFPSSGVLIFGKTGATNKTTLENVLMTNEEE IRPTNPVATEEYGIVSSNLQAANTAAQTQVVNNQGALPGMVWQNRDVYLQGPIWAKIP HTDGNFHPSPLMGGFGLKHPPPQILIKNTPVPANPPEVFTPAKFASFITQYSTGQVSV EIEWELQKENSKRWNPEIQYTSNFEKQTGVDFAVDSQGVYSEPRPIGTRYLTRNL" /product="capsid protein" /note="similar to AAV2 VP1 protein" ORIGIN 1 ttggccactc cctctatgcg cgctcgctcg ctcggtgggg cctgcggacc aaaggtccgc 61 agacggcaga gctctgctct gccggcccca ccgagcgagc gagcgcgcat agagggagtg 121 gccaactcca tcactagggg taccgcgaag cgcctcccac gctgccgcgt cagcgctgac 181 gtaaatcacg tcatagggga gtggtcctgt attagctgtc acgtgagtgc ttttgcgaca 241 ttttgcgaca ccacgtggcc atttgaggta tatatggccg agtgagcgag caggatctcc 301 attttgaccg cgaaatttga acgagcagca gccatgccgg gtttctacga gatcgtgatc 361 aaggtgccga gcgacctgga cgagcacctg ccgggcattt ctgactcgtt tgtgaactgg 421 gtggccgaga aggaatggga gctgcccccg gattctgaca tggatctgaa tctgatcgag 481 caggcacccc tgaccgtggc cgagaagctg cagcgcgact tcctggtcca atggcgccgc 541 gtgagtaagg ccccggaggc cctgttcttt gttcagttcg agaagggcga gagctacttc 601 caccttcacg ttctggtgga gaccacgggg gtcaagtcca tggtgctagg ccgcttcctg 661 agtcagattc gggagaagct ggtccagacc atctaccgcg gggtcgagcc cacgctgccc 721 aactggttcg cggtgaccaa gacgcgtaat ggcgccggcg gggggaacaa ggtggtggac 781 gagtgctaca tccccaacta cctcctgccc aagacccagc ccgagctgca gtgggcgtgg 841 actaacatgg aggagtatat aagcgcgtgt ttgaacctgg ccgaacgcaa acggctcgtg 901 gcgcagcacc tgacccacgt cagccagacg caggagcaga acaaggagaa tctgaacccc 961 aattctgacg cgcccgtgat caggtcaaaa acctccgcgc gctacatgga gctggtcggg 1021 tggctggtgg accggggcat cacctccgag aagcagtgga tccaggagga ccaggcctcg 1081 tacatctcct tcaacgccgc ctccaactcg cggtcccaga tcaaggccgc gctggacaat 1141 gccggcaaga tcatggcgct gaccaaatcc gcgcccgact acctggtggg gccctcgctg 1201 cccgcggaca ttaaaaccaa ccgcatctac cgcatcctgg agctgaacgg gtacgatcct 1261 gcctacgccg gctccgtctt tctcggctgg gcccagaaaa agttcgggaa gcgcaacacc 1321 atctggctgt ttgggcccgc caccaccggc aagaccaaca ttgcggaagc catcgcccac 1381 gccgtgccct tctacggctg cgtcaactgg accaatgaga actttccctt caacgattgc 1441 gtcgacaaga tggtgatctg gtgggaggag ggcaagatga cggccaaggt cgtggagtcc 1501 gccaaggcca ttctcggcgg cagcaaggtg cgcgtggacc aaaagtgcaa gtcgtccgcc 1561 cagatcgacc ccacccccgt gatcgtcacc tccaacacca acatgtgcgc cgtgattgac 1621 gggaacagca ccaccttcga gcaccagcag ccgttgcagg accggatgtt caaatttgaa 1681 ctcacccgcc gtctggagca cgactttggc aaggtgacga agcaggaagt caaagagttc 1741 ttccgctggg ccagtgatca cgtgaccgag gtggcgcatg agttctacgt cagaaagggc 1801 ggagccagca aaagacccgc ccccgatgac gcggatataa gcgagcccaa gcgggcctgc 1861 ccctcagtcg cggatccatc gacgtcagac gcggaaggag ctccggtgga ctttgccgac 1921 aggtaccaaa acaaatgttc tcgtcacgcg ggcatgattc agatgctgtt tccctgcaaa 1981 acgtgcgaga gaatgaatca gaatttcaac atttgcttca cacacggggt cagagactgt 2041 ttagagtgtt tccccggcgt gtcagaatct caaccggtcg tcagaaaaaa gacgtatcgg 2101 aaactctgcg cgattcatca tctgctgggg cgggcgcccg agattgcttg ctcggcctgc 2161 gacctggtca acgtggacct ggacgactgc gtttctgagc aataaatgac ttaaaccagg 2221 tatggctgcc gatggttatc ttccagattg gctcgaggac aacctctctg agggcattcg 2281 cgagtggtgg gacctgaaac ctggagcccc gaaacccaaa gccaaccagc aaaagcagga 2341 caacggccgg ggtctggtgc ttcctggcta caagtacctc ggacccttca acggactcga 2401 caagggggag cccgtcaacg cggcggacgc agcggccctc gagcacgaca aggcctacga 2461 ccagcagctc aaagcgggtg acaatccgta cctgcggtat aaccacgccg acgccgagtt 2521 tcaggagcgt ctgcaagaag atacgtcatt tgggggcaac ctcgggcgag cagtcttcca 2581 ggccaagaag cgggttctcg aacctctcgg tctggttgag gaaggcgcta agacggctcc 2641 tgcaaagaag agaccggtag agccgtcacc tcagcgttcc cccgactcct ccacgggcat 2701 cggcaagaaa ggccagcagc ccgccagaaa gagactcaat ttcggtcaga ctggcgactc 2761 agagtcagtc cccgaccctc aacctctcgg agaacctcca gcagcgccct ctagtgtggg 2821 atctggtaca gtggctgcag gcggtggcgc accaatggca gacaataacg aaggtgccga 2881 cggagtgggt aatgcctcag gaaattggca ttgcgattcc acatggctgg gcgacagagt 2941 cattaccacc agcacccgaa cctgggccct gcccacctac aacaaccacc tctacaagca 3001 aatctccagt gaaactgcag gtagtaccaa cgacaacacc tacttcggct acagcacccc 3061 ctgggggtat tttgacttta acagattcca ctgccacttc tcaccacgtg actggcagcg 3121 actcatcaac aacaactggg gattccggcc caagaagctg cggttcaagc tcttcaacat 3181 ccaggtcaag gaggtcacga cgaatgacgg cgttacgacc atcgctaata accttaccag 3241 cacgattcag gtattctcgg actcggaata ccagctgccg tacgtcctcg gctctgcgca 3301 ccagggctgc ctgcctccgt tcccggcgga cgtcttcatg attcctcagt acggctacct 3361 gactctcaac aatggcagtc agtctgtggg acgttcctcc ttctactgcc tggagtactt 3421 cccctctcag atgctgagaa cgggcaacaa ctttgagttc agctacagct tcgaggacgt 3481 gcctttccac agcagctacg cacacagcca gagcctggac cggctgatga atcccctcat 3541 cgaccagtac ttgtactacc tggccagaac acagagtaac ccaggaggca cagctggcaa 3601 tcgggaactg cagttttacc agggcgggcc ttcaactatg gccgaacaag ccaagaattg 3661 gttacctgga ccttgcttcc ggcaacaaag agtctccaaa acgctggatc aaaacaacaa 3721 cagcaacttt gcttggactg gtgccaccaa atatcacctg aacggcagaa actcgttggt 3781 taatcccggc gtcgccatgg caactcacaa ggacgacgag gaccgctttt tcccatccag 3841 cggagtcctg atttttggaa aaactggagc aactaacaaa actacattgg aaaatgtgtt 3901 aatgacaaat gaagaagaaa ttcgtcctac taatcctgta gccacggaag aatacgggat 3961 agtcagcagc aacttacaag cggctaatac tgcagcccag acacaagttg tcaacaacca 4021 gggagcctta cctggcatgg tctggcagaa ccgggacgtg tacctgcagg gtcccatctg 4081 ggccaagatt cctcacacgg atggcaactt tcacccgtct cctttgatgg gcggctttgg 4141 acttaaacat ccgcctcctc agatcctgat caagaacact cccgttcccg ctaatcctcc 4201 ggaggtgttt actcctgcca agtttgcttc gttcatcaca cagtacagca ccggacaagt 4261 cagcgtggaa atcgagtggg agctgcagaa ggaaaacagc aagcgctgga acccggagat 4321 tcagtacacc tccaactttg aaaagcagac tggtgtggac tttgccgttg acagccaggg 4381 tgtttactct gagcctcgcc ctattggcac tcgttacctc acccgtaatc tgtaattgca 4441 tgttaatcaa taaaccggtt gattcgtttc agttgaactt tggtctcctg tgcttcttat 4501 cttatcggtt tccatagcaa ctggttacac attaactgct tgggtgcgct tcacgataag 4561 aacactgacg tcaccgcggt acccctagtg atggagttgg ccactccctc tatgcgcgct 4621 cgctcgctcg gtggggcctg cggaccaaag gtccgcagac ggcagagctc tgctctgccg 4681 gccccaccga gcgagcgagc gcgcatagag ggagtggcca a //