LOCUS NC_003900 11824 bp ss-RNA linear VRL 10-FEB-2015 DEFINITION Aura virus, complete genome. ACCESSION NC_003900 VERSION NC_003900.1 DBSOURCE BioProject accession PRJNA14830 KEYWORDS RefSeq. SOURCE Aura virus ORGANISM Aura virus Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Togaviridae; Alphavirus. REFERENCE 1 (bases 1 to 11824) AUTHORS Rumenapf,T., Strauss,E.G. and Strauss,J.H. TITLE Aura virus is a New World representative of Sindbis-like viruses JOURNAL Virology 208 (2), 621-633 (1995) PUBMED 7747434 REFERENCE 2 (bases 1 to 11824) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (05-MAY-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 11824) AUTHORS Ruemenapf,T.H. TITLE Direct Submission JOURNAL Submitted (08-FEB-1999) Vet. Virology, Justus-Liebig University, Frankfurter Str. 107, Giessen D-35392, Germany COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF126284. The mature peptides were predicted and annotated at the NCBI by analogy with the annotation of the genome of Semliki forest virus (NC_003215) and other alphaviruses. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..11824 /mol_type="genomic RNA" /db_xref="taxon:44158" /organism="Aura virus" gene 78..7577 /locus_tag="AURAVgp1" /db_xref="GeneID:944525" CDS 78..7577 /locus_tag="AURAVgp1" /protein_id="NP_632023.2" /note="The mature peptides were predicted and annotated at the NCBI by analogy with the annotation of the genome of Semliki forest virus (NC_003215) and other alphaviruses; Inferred from its homology with non-structural polyprotein precursor nsP1234 of Sindbis virus (PMID 2521676 and PMID 3339717). Contains leaky opal termination codon" /db_xref="GeneID:944525" /codon_start=1 /inference="non-experimental evidence, no additional details recorded" /translation="MEKPTVHVDVDPQSPFVLQLQKSFPQFEIVAQQVTPNDHANARA FSHLASKLIEHEIPTSVTILDIGSAPARRMYSEHKYHCVCPMRSPEDPDRLMNYASRL ADKAGEITNKRLHDKLADLKSVLESPDAETGTICFHNDVICRTTAEVSVMQNVYINAP STIYHQALKGVRKLYWIGFDTTQFMFSSMAGSYPSYNTNWADERVLEARNIGLCSTKL REGTMGKLSTFRKKALKPGTNVYFSVGSTLYPENRADLQSWHLPSVFHLKGKQSFTCR CDTAVNCEGYVVKKITISPGITGRVNRYTVTNNSEGFLLCKITDTVKGERVSFPVCTY IPPSICDQMTGILATDIQPEDAQKLLVGLNQRIVVNGKTNRNTNTMQNYLLPAVATGL SKWAKERKADCSDEKPLNVRERKLAFGCLWAFKTKKIHSFYRPPGTQTIVKVAAEFSA FPMSSVWTTSLPMSLRQKVKLLLVKKTNKPVVTITDTAVKNAQEAYNEAVETAEAEEK AKALPPLKPTAPPVAEDVKCEVTDLVDDAGAALVETPRGKIKIIPQEGDVRIGSYTVI SPAAVLRNQQLEPIHELAEQVKIITHGGRTGRYSVEPYDAKVLLPTGCPMSWQHFAAL SESATLVYNEREFLNRKLHHIATKGAAKNTEEEQYKVCKAKDTDHEYVYDVDARKCVK REHAQGLVLVGELTNPPYHELAYEGLRTRPAAPYHIETLGVIGTPGSGKSAIIKSTVT LKDLVTSGKKENCKEIENDVQKMRGMTIATRTVDSVLLNGWKKAVDVLYVDEAFACHA GTLMALIAIVKPRRKVVLCGDPKQWPFFNLMQLKVNFNNPERDLCTSTHYKYISRRCT QPVTAIVSTLHYDGKMRTTNPCKRAIEIDVNGSTKPKKGDIVLTCFRGWVKQGQIDYP GPGGHDRAASQGLTRRGVYAVRQKVNENPLYAEKSEHVNVLLTRTEDRIVWKTLQGDP WIKYLTNVPKGNFTATLEEWQAEHEDIMKAINSTSTVSDPFASKVNTCWAKAIIPILR TAGIELTFEQWEDLFPQFRNDQPYSVMYALDVICTKMFGMDLSSGIFSRPEIPLTFHP ADVGRVRAHWDNSPGGQKFGYNKAVIPTCKKYPVYLRAGKGDQILPIYGRVSVPSARN NLVPLNRNLPHSLTASLQKKEAAPLHKFLNQLPGHSMLLVSKETCYCVSKRITWVAPL GVRGADHNHDLHFGFPPLSRYDLVVVNMGQPYRFHHYQQCEEHAGLMRTLARSALNCL KPGGTLALKAYGFADSNSEDVVLSLARKFVRASAVRPSCTQFNTEMFFVFRQLDNDRE RQFTQHHLNLAVSNIFDNYKDGSGAAPSYRVKRMNIADCTEEAVVNAANARGKPGDGV CRAIFKKWPKSFENATTEVETAVMKPCHNKVVIHAVGPDFRKYTLEEATKLLQNAYHD VAKIVNEKGISSVAIPLLSTGIYAAGADRLDLSLRCLFTALDRTDADVTIYCLDKKWE QRIADAIRMREQVTELKDPDIEIDEGLTRVHPDSCLKDHIGYSTQYGKLYSYFEGTKF HQTAKDIAEIRALFPDVQAANEQICLYTLGEPMESIREKCPVEDSPASAPPKTIPCLC MYAMTAERICRVRSNSVTNITVCSSFPLPKYRIKNVQKIQCTKVVLFNPDVPPYIPAR VYINKDEPPVTPHTDSPPDTCSSRLSLTPTLSNAESDIVSLTFSEIDSELSSLNEPAR HVMISSFKLRYTAIQALPQKLSWMREDRTPRQPPPVPPPRPKRAAKLSRLANQLNELR RHATISSVQAEVHYNSGFTPEAELNERGSILRKPPPVPPLRPKQTTNLSRLANQLSMP ITFGDFAEGELDRLLTPSPTPTFGDFSQEEMDRFFGNRQYWLTGVGGYIFSSDTGPGH LQQKSVIQNSTTEILIERSRLEKIHAPVLDLQKEEMLKCRYQMSPTVANKSRYQSRKV ENMKAVTTGRLLDGLKMYVTPDVEAECYKYTYPKPMYSASVPDRFVSPEVAVAVCNNF FHENYPTVASYQITDEYDAYLDMVEGSVSCLDTATFCPAKLRSFPKTHSYLEPTLRSA VPSAFQNTLQNVLSAATKRNCNVTQMRELPVLDSAVFNVECFKKYACNTDYWEEFKEK PIRITTECVTSYVARLKGPEAAALFAKTHQLVPLQEVPMDRFVMDMKRDVKVTPGTKH TEERPKVQVIQAAEPLATAYLCGIHRELVRRLTAVLLPNIHTLFDMSAEDFDAIIAAN FSYVHPVLETDIGSFDKSQDDSLALTALMILEDLGVDDRLMDLIECAFGEITSVHLPT ATTFKFGAMMKSGMFLTLFVNTVLNVVIASRVLEQRLRDSKCAAFIGDDNIIHGVVSD KIMADRCATWMNMEVKIIDAVIGIKAPYFCGGFILEDQVTHTACRVSDPLKRLFKLGK PLPVDDEQDHDRRRALEDETRAWFRVGIQGELLKAVESRYEVQEVQPVLLALATFSRS DKAFKALRGSPRHLYGGPK" /product="Polyprotein 1" /transl_except=(pos:5724..5726,aa:Trp) mat_peptide 78..5744 /locus_tag="AURAVgp1" /protein_id="NP_819014.1" /product="Nonstructural protein P123" /note="together with nsP4, constitutes the minus-strand polymerase" mat_peptide 78..1694 /locus_tag="AURAVgp1" /protein_id="NP_819010.1" /product="Nonstructural protein nsP1" /note="capping enzyme and polymerase complex component; involved in initiation of negative strand RNA synthesis; in SFV nsP1, residues 245-264 are responsible for binding with anionic membrane phospholipids; probably mediates association of viral replicative complex with membranes; guanine-7N-methyltransferase; guanylyltransferase" mat_peptide 1695..4112 /locus_tag="AURAVgp1" /protein_id="NP_819011.1" /product="NTPase" /note="viral RNA capping enzyme and polymerase complex component; the NTPase/RNA helicase/5'-triphosphatase domain is located in the N-terminal half of the protein and the proteinase at the C-terminus; the proteinase domain mediates nonstructural polyprotein processing; Nonstructural protein nsP2; RNA 5'-triphosphatase; papain-like proteinase" mat_peptide 4113..5744 /locus_tag="AURAVgp1" /protein_id="NP_819012.1" /product="Nonstructural protein nsP3" /note="phosphoprotein, polymerase complex component; predicted phosphoesterase (similar to the Appr-1'-p processing enzyme) formerly known as 'X-domain'; together with the membrane binding nsP1 domain, SFV nsP3 mediates targeting the non-structural polyprotein to the endosome." mat_peptide 5745..7574 /locus_tag="AURAVgp1" /protein_id="NP_819013.1" /product="Nonstructural protein nsP4" /note="RNA-dependent RNA polymerase catalytic subunit" gene 7628..11362 /locus_tag="AURAVgp2" /db_xref="GeneID:944526" CDS 7628..11362 /locus_tag="AURAVgp2" /db_xref="GeneID:944526" /codon_start=1 /protein_id="NP_632024.1" /translation="MNSVFYNPFGRGAYAQPPIAWRPRRRAAPAPRPSGLTTQIQQLT RAVRALVLDNATRRQRPAPRTRPRKPKTQKPKPKKQNQKPPQQQKKGKNQPQQPKKPK PGKRQRTALKFEADRTFVGKNEDGKIMGYAVAMEGKVIKPLHVKGTIDHPALAKLKFT KSSSYDMEFAKLPTEMKSDAFGYTTEHPEVFYNWHHGAVQFSGGRFTIPTGVGGPGDS GRPILDNSGKVVAIVLGGANEVPGTALSVVTWNKKGAAIKTTHEDTVEWSRAITAMCI LQNVTFPCDRPPTCYNRNPDLTLTMLETNVNHPSYDVLLDAALRCPTRRHVRSTPTDD FTLTAPYLGLCHRCKTMEPCYSPIKIEKVWDDADDGVLRIQVSAQLGYNRAGTAASAR LRFMGGGVPPEIQEGAIADFKVFTSKPCLHLSHKGYFVIVKCPPGDSITTSLKVHGSD QTCTIPMRVGYKFVGREKYTLPPMHGTQIPCLTYERTREKSAGYVTMHRPGQQSITML MEESGGEVYVQPTSGRNVTYECKCGDFKTGTVTARTKIDGCTERKQCIAISADHVKWV FNSPDLIRHTDHTAQGKLHIPFPLQQAQCTVPLAHLPGVKHAYRSMSLTLHAEHPTLL TTRHLGENPQPTAEWIVGSVTRNFSITIQGFEYTWGNQKPVRVYAQESAPGNPHGWPH EIVRHYYHLYPFYTVTVLSGMGLAICAGLVISILCCCKARRDCLTPYQLAPNATVPFL VTLCCCFQRTSADEFTDTMGYLWQHSQTMFWIQLVIPLAAVITLVRCCSCCLPFLLVA SPPNKADAYEHTITVPNAPLNSYKALVERPGYAPLNLEVMVMNTQIIPSVKREYITCR YHTVVPSPQIKCCGTVECPKGEKADYTCKVFTGVYPFLWGGAQCFCDSENSQLSDKYV ELSTDCATDHAEAVRVHTASVKSQLRITYGNSTAQVDVFVNGVTPARSKDMKLIAGPL STTFSPFDNKVIIYHGKVYNYDFPEFGAGTPGAFGDVQASSTTGSDLLANTAIHLQRP EARNIHVPYTQAPSGFEFWKNNSGQPLSDTAPFGCKVNVNPLRADKCAVGSLPISVDI PDAAFTRVSEPLPSLLKCTVTSCTYSTDYGGVLVLTYESDRAGQCAVHSHSSTAVLRD PSVYVEQKGETTLKFSTRSLQADFEVSMCGTRTTCHAQCQPPTEHVMNRPQKSTPDFS SAISKTSWNWITALMGGISSIAAIAAIVLVIALVFTAQHR" /product="Polyprotein 2" /note="The mature peptides were predicted and annotated at the NCBI by analogy with the annotation of the genome of Semliki forest virus (NC_003215) and other alphaviruses; Structural polyprotein" mat_peptide 7628..8428 /locus_tag="AURAVgp2" /protein_id="NP_819015.1" /product="C protein" /note="the capsid protein is a serine proteinase that releases itself from the precursor" mat_peptide 8429..8611 /locus_tag="AURAVgp2" /protein_id="NP_819016.1" /product="E3 protein" /note="In some alphaviruses, E3 was not detected" mat_peptide 8612..9883 /locus_tag="AURAVgp2" /protein_id="NP_819017.1" /product="E2 protein" mat_peptide 9884..10045 /locus_tag="AURAVgp2" /protein_id="NP_819018.1" /product="6K protein" mat_peptide 10046..11359 /locus_tag="AURAVgp2" /protein_id="NP_819019.1" /product="E1 protein" gene 7628..10032 /locus_tag="AURAVgp3" /db_xref="GeneID:13165419" CDS join(7628..10012,10012..10032) /locus_tag="AURAVgp3" /db_xref="GeneID:13165419" /codon_start=1 /protein_id="YP_006491231.1" /translation="MNSVFYNPFGRGAYAQPPIAWRPRRRAAPAPRPSGLTTQIQQLT RAVRALVLDNATRRQRPAPRTRPRKPKTQKPKPKKQNQKPPQQQKKGKNQPQQPKKPK PGKRQRTALKFEADRTFVGKNEDGKIMGYAVAMEGKVIKPLHVKGTIDHPALAKLKFT KSSSYDMEFAKLPTEMKSDAFGYTTEHPEVFYNWHHGAVQFSGGRFTIPTGVGGPGDS GRPILDNSGKVVAIVLGGANEVPGTALSVVTWNKKGAAIKTTHEDTVEWSRAITAMCI LQNVTFPCDRPPTCYNRNPDLTLTMLETNVNHPSYDVLLDAALRCPTRRHVRSTPTDD FTLTAPYLGLCHRCKTMEPCYSPIKIEKVWDDADDGVLRIQVSAQLGYNRAGTAASAR LRFMGGGVPPEIQEGAIADFKVFTSKPCLHLSHKGYFVIVKCPPGDSITTSLKVHGSD QTCTIPMRVGYKFVGREKYTLPPMHGTQIPCLTYERTREKSAGYVTMHRPGQQSITML MEESGGEVYVQPTSGRNVTYECKCGDFKTGTVTARTKIDGCTERKQCIAISADHVKWV FNSPDLIRHTDHTAQGKLHIPFPLQQAQCTVPLAHLPGVKHAYRSMSLTLHAEHPTLL TTRHLGENPQPTAEWIVGSVTRNFSITIQGFEYTWGNQKPVRVYAQESAPGNPHGWPH EIVRHYYHLYPFYTVTVLSGMGLAICAGLVISILCCCKARRDCLTPYQLAPNATVPFL VTLCCCFQRTSADEFTDTMGYLWQHSQTMFWIQLVIPLAAVITLVRCCSCCLPFLIGC QSS" /product="truncated polyprotein" /note="Truncated verstion of structural polyprotein that will be produced when frameshifting occurs at nt 10012; Truncated version of structural polyprotein and transframe fusion protein have been added by NCBI Staff with the kind help of Dr. David Karlin (Department of Zoology, University of Oxford, UK) and Dr. Andrew Firth (Department of Pathology, University of Cambridge, UK)" mat_peptide join(9884..10012,10012..10029) /locus_tag="AURAVgp3" /protein_id="YP_006491232.1" /product="transframe fusion polyprotein" /note="Transframe fusion (TF) protein expressed via programmed ribosomal frameshifting. TF protein presumably plays a stabilizing role in the virion structure." ORIGIN 1 atagcggacg gactagtact tgtactacag aattaactgc cgtgtgccgc ccgctaaact 61 agccccaatc atcgaaaatg gagaaaccga cagtgcacgt tgacgtagac ccccaaagtc 121 cgtttgtgct acaactgcag aagagtttcc cacaattcga gattgtggct cagcaggtca 181 ctccgaatga ccatgctaat gccagagctt tttcgcatct ggctagtaaa ctgatcgaac 241 atgagatccc cacctcagtt acgatcttgg acataggaag cgcaccagct cgtagaatgt 301 attccgagca taagtatcac tgtgtgtgcc ccatgcgtag tcctgaagac ccggaccgtc 361 ttatgaatta cgcatcccga ctcgcagaca aagcagggga aattaccaac aagaggctgc 421 atgataaact tgcagacctc aagtcggtcc tcgagtcgcc ggatgctgaa actggtacca 481 tttgtttcca caatgacgta atatgccgta cgacagcgga ggtatcagtt atgcaaaatg 541 tgtatatcaa tgcaccttcg accatttacc atcaggccct aaagggagtc agaaaactgt 601 attggatcgg gttcgataca acgcagttta tgttctcctc gatggcaggg tcgtatccgt 661 cctacaatac taattgggcc gatgaaaggg tgctggaagc gcgtaatata ggcctatgta 721 gcacgaagct gagagagggt acgatgggca aactgtctac cttccggaaa aaggccttga 781 aacctggaac taacgtgtac ttctctgtcg gttcgacact ctaccctgag aatagagcgg 841 acctgcagag ttggcaccta ccatctgtgt tccacttgaa aggtaaacaa tcctttacgt 901 gccgctgtga tacggcggtt aactgcgaag gatacgtagt caagaagatc accatcagcc 961 ccgggatcac ggggcgtgtc aatcggtaca ctgtgactaa caacagcgag ggattcttgc 1021 tgtgtaagat cacagatacg gtcaaagggg agcgtgtatc gttccctgtc tgtacgtata 1081 ttccaccttc aatctgtgac caaatgacag gtatattggc cactgatatc caacccgaag 1141 acgcgcaaaa gttgctggta ggactgaacc aacgcatagt cgtgaacgga aaaactaata 1201 gaaacaccaa cacgatgcag aactatctcc tgcccgcggt ggctacaggt ctgagtaaat 1261 gggccaaaga aagaaaggca gactgcagtg acgagaaacc attgaatgtg agagaacgca 1321 aactagcttt cggttgccta tgggctttca agaccaagaa gatccattct ttttaccgcc 1381 cgccaggcac gcagactata gtaaaagtcg cagcggaatt cagtgcgttc cctatgtcct 1441 cggtgtggac tacgtcactg ccaatgtcac tgagacagaa agttaaactg cttcttgtaa 1501 agaaaaccaa taaaccggta gtcactatta ctgacactgc ggtaaaaaac gcacaagagg 1561 catataacga agccgtcgag acagcagaag cggaggagaa agcgaaggcc ttacctccgc 1621 tgaagccgac ggcaccccct gtagcggagg acgtcaaatg cgaggtcacc gacctggtag 1681 acgatgcggg agcggccctg gtcgagacgc cccggggaaa gataaaaatt atcccacagg 1741 aaggggacgt gcgtattggt tcctacacag tcatttctcc agcggcagtc cttagaaatc 1801 aacaactgga gccaatccac gagttagcag agcaggtgaa aattatcacg cacggtggcc 1861 gaacaggcag gtattccgtc gaaccttacg atgctaaggt tctcctgcca acaggatgcc 1921 ccatgtcctg gcaacatttc gcggccttga gcgaaagcgc tacgttagtc tacaatgaga 1981 gagagttcct gaaccggaaa ctccatcaca tcgctacgaa gggtgcggca aaaaacactg 2041 aggaagaaca atacaaagta tgcaaagcta aagacacgga tcatgagtac gtatacgacg 2101 tagatgccag aaaatgcgta aaaagagagc atgcacaagg gctagtacta gttggggaac 2161 taactaatcc gccttaccac gagctggcat acgaaggatt acgtacacga cccgctgccc 2221 cttaccatat cgaaacactg ggggtcattg gaacaccggg gtcaggtaag tcggccatca 2281 taaaatctac ggtaacacta aaagacctcg taactagcgg taagaaagaa aattgcaaag 2341 aaatagagaa tgacgtccag aaaatgcggg gaatgactat agctacgaga acggtagact 2401 cggtacttct taatggatgg aagaaagcag tagacgtcct atatgtggat gaagcgtttg 2461 catgtcatgc aggcacctta atggcattga ttgccattgt caaaccgaga cgtaaagtag 2521 tactgtgcgg cgacccgaag cagtggccct tctttaattt aatgcaactg aaggtaaact 2581 tcaacaaccc cgagcgagac ctgtgtactt ccacccatta taaatatatc tctcgcaggt 2641 gcacccaacc tgttacagcc atagtgtcta cattacacta tgacggaaag atgaggacta 2701 cgaatccctg caaaagggct atcgaaatag acgtaaacgg atcgactaag cccaagaaag 2761 gagacatagt gttgacgtgt ttccgtgggt gggttaagca ggggcaaatc gattaccccg 2821 gacccggagg tcatgaccgt gcagcttctc aagggctaac cagaaggggc gtttatgcgg 2881 tcagacagaa agtaaatgaa aacccactat atgcagagaa gtcagaacac gttaacgtgt 2941 tacttactag gacggaagat cgcatagtgt ggaagacact gcaaggggat ccttggatta 3001 agtacctcac taacgttcca aaagggaact ttacagccac tttagaagaa tggcaggcgg 3061 aacacgagga cattatgaag gccattaatt ctacatccac agtatctgac cctttcgcca 3121 gcaaagtgaa tacatgctgg gctaaagcta ttatacccat cctaagaacg gcagggatag 3181 aacttacatt cgagcagtgg gaagatctat tcccgcaatt tcgtaatgac caaccttact 3241 ccgtgatgta tgccctagat gtgatatgta ccaagatgtt cggcatggat ctgagcagtg 3301 ggatcttctc tcgtcctgag atacctctaa cgttccatcc cgcggacgtc ggccgagtga 3361 gagctcactg ggataactcc ccaggagggc agaagtttgg gtataacaag gcggtaatcc 3421 caacttgcaa gaaataccca gtgtacttaa gagcaggaaa aggggaccaa atactcccca 3481 tatatggcag agtttcagtc ccatcggcac ggaacaattt agttccctta aacagaaatc 3541 taccacactc gctaactgca agcctgcaga aaaaagaagc agctcccttg cacaagttcc 3601 ttaaccaact accaggacac agtatgctgc tggtctctaa ggaaacatgc tattgcgtgt 3661 ccaagcgaat cacatgggtc gctccgctgg gagtcagagg agctgaccac aaccatgacc 3721 tgcatttcgg gttcccacca ctgtccagat acgaccttgt ggtggttaat atgggacaac 3781 cgtacaggtt ccatcactac cagcagtgcg aggagcatgc cggcctcatg aggacgttgg 3841 cccggtcagc actcaactgc ctaaaaccag gaggaacatt agccctgaaa gcatatggtt 3901 tcgccgactc caatagtgag gacgttgttc tgtctttagc gaggaaattc gtgcgggcat 3961 ccgcagtgag accatcgtgt acacagttta acacagagat gttctttgta tttaggcagc 4021 tggacaacga tcgtgagcgc caattcactc agcatcactt gaatttagca gtatccaata 4081 tattcgacaa ttataaagac ggatccggag cagctccttc ttatcgcgtt aagagaatga 4141 atatcgcaga ctgcacagaa gaagcagtgg tgaacgcagc taacgcgcgg ggaaaacctg 4201 gggacggagt atgcagagct atcttcaaaa agtggccgaa gtcatttgag aacgctacca 4261 ctgaagtgga aaccgcggtc atgaaaccat gccacaacaa ggttgttata catgcagtgg 4321 gtcctgattt tagaaagtac acgttggagg aagcgacgaa gctactgcag aacgcatacc 4381 atgatgtggc aaagatagtg aacgagaaag gcatctcctc ggtagctata ccgctgctct 4441 caacaggtat ctatgctgcc ggagctgatc gcctggatct ctcgctgaga tgtcttttca 4501 ccgcgctgga tcgtacggat gcggatgtca caatatattg cctagataag aagtgggagc 4561 aacgcatagc agatgctatt aggatgcgag aacaagtaac tgaattaaaa gatccggaca 4621 tagagataga tgaaggatta acccgggtac acccagatag ctgcctcaag gatcacatag 4681 gctacagtac ccagtatggg aaattgtact catactttga aggtactaaa ttccaccaaa 4741 ccgcaaaaga catagccgag attcgtgcgc tgtttcctga tgtacaagcc gctaacgaac 4801 aaatctgcct gtacacttta ggcgaaccga tggagtccat acgcgaaaag tgcccagtcg 4861 aagactcccc ggcatcagca cctcctaaga caataccttg cctatgtatg tatgctatga 4921 cagccgaacg tatttgccgc gtacgcagta actccgtaac gaacataacg gtgtgctcat 4981 cctttccgtt acccaagtac cgaataaaga acgtacaaaa gatacagtgc acgaaagtcg 5041 tgctatttaa cccggatgta ccgccctaca ttcccgcgag agtatacatt aacaaggacg 5101 agcctcctgt tactccccat accgacagcc cgccggacac ttgctcttcg aggctatcgc 5161 tgacgcccac gctctctaac gcagaatcgg atatcgtatc tctaacgttt tcggaaatcg 5221 atagcgagct gtcgtcacta aacgagcctg cgaggcacgt aatgatatcc tcgttcaagc 5281 tgaggtacac tgcgatccag gctttacctc agaagctgag ttggatgaga gaggatcgca 5341 caccgagaca gccgcctcct gtaccgccac cacgaccaaa acgagccgcg aaattatccc 5401 gactagcaaa ccagctaaac gagctacgga ggcatgcgac gatatcctcc gttcaagctg 5461 aggtacacta caattcaggt tttaccccag aagccgaatt gaatgagaga ggatcgatac 5521 tgaggaagcc gcctcccgta ccgccactac gaccaaaaca aactacgaac ttatctcgac 5581 tcgcaaacca actatctatg ccgataacat tcggagattt tgccgaagga gagctagaca 5641 ggctgctaac gccatcaccg acccctacgt ttggggactt ctctcaggaa gaaatggata 5701 gattcttcgg aaacagacaa tattgactaa ccggggtagg tgggtacata ttctcttctg 5761 atacaggccc ggggcatctg caacaaaaat cagttattca aaacagcacc accgagatac 5821 taatagaacg aagtagacta gaaaaaattc atgcccctgt actggaccta cagaaagaag 5881 agatgctgaa gtgtaggtac cagatgtcac ccaccgtagc caacaagagc aggtaccagt 5941 cacggaaagt agagaacatg aaagcagtga cgacagggag gttgttagat ggtctgaaaa 6001 tgtacgtcac cccggacgtt gaagcagaat gctacaagta cacgtatcca aaaccgatgt 6061 attctgccag cgtgcctgac cgcttcgtat cacctgaagt ggcagtagcg gtctgcaaca 6121 acttcttcca tgagaattat cctacggtag cctcttacca gataactgac gagtacgatg 6181 cctacttaga catggtcgag gggtctgtat cgtgtttaga tactgctaca ttctgcccag 6241 cgaaactgag gagcttccca aagacacact cttacctgga acctacgttg cggagtgcgg 6301 ttccatcggc gtttcagaac accctgcaaa acgtattatc agcagctact aaaaggaact 6361 gcaatgtaac acaaatgaga gaactgcctg tgctagattc cgccgtgttc aatgtggagt 6421 gctttaaaaa gtatgcatgt aatacagact actgggaaga atttaaagag aaaccaataa 6481 gaataacaac agagtgtgtc acctcatacg tggcccgatt aaaaggaccg gaagctgcag 6541 cactattcgc aaagacacat caactggtcc cgctacagga ggtccctatg gataggtttg 6601 taatggacat gaaaagagat gtaaaggtga cacccggcac taaacatacc gaagagcgtc 6661 ccaaggtgca agttattcaa gcagcagaac cactggccac ggcttacttg tgcggtatac 6721 accgggagct agtacggagg cttacagcag tactgttacc taacatccat acactattcg 6781 acatgtctgc cgaggatttc gacgcgatca tagcagcaaa tttttcttac gtgcacccgg 6841 tgctagaaac agatataggc tctttcgaca agagccagga tgattcatta gccctgactg 6901 cactgatgat tctggaagac ttaggagtgg atgaccgcct gatggacctc attgaatgtg 6961 ccttcgggga gatcacaagc gtccacctac cgacagcaac cacgtttaaa tttggtgcta 7021 tgatgaagtc cggaatgttt ttaacactgt ttgttaacac tgtgttgaat gtagttattg 7081 ctagccgagt tctagaacaa cggttgaggg actccaaatg cgcagctttc ataggggacg 7141 acaacattat acatggtgtc gtttcggaca agataatggc cgacagatgc gccacttgga 7201 tgaatatgga agtgaaaatc atagacgcgg tcattggtat caaggcccct tacttttgcg 7261 gcggatttat tctagaagac caagtgacgc acacagcgtg ccgggtctct gatccgctta 7321 agagactgtt caaactaggc aagcctctac cagtagatga tgagcaggat cacgacaggc 7381 gtagagcgct ggaagatgag acaagggcgt ggttcagagt ggggatccaa ggagaacttt 7441 tgaaggccgt cgagtcacgc tatgaggtac aagaggttca gccagtgctg ttagccctcg 7501 ctacgttctc gcgtagcgat aaagcattta aagcactacg cgggagccca agacacctct 7561 acggtggtcc taaatagacg gtgtagcaca gtagatcgtc taaattattt cacatcttta 7621 cgttactatg aactctgtct tttacaatcc gtttggccga ggtgcctacg ctcaacctcc 7681 aatagcatgg aggccaagac gtagggctgc acctgcgcct cgaccatccg ggttgactac 7741 ccagatccaa cagctcacta gggctgttag agctttggtg ctggacaatg ctacacgtcg 7801 ccagcgcccg gctcctcgca cgcgcccgag gaagccgaag actcaaaaac ctaagccgaa 7861 gaagcaaaac cagaaaccac cacaacagca gaagaaaggg aaaaatcagc cccaacaacc 7921 gaagaaaccg aagcccggta aacgacagcg taccgccctg aaatttgaag ccgaccgcac 7981 atttgtcggg aagaatgaag acggcaagat tatgggatac gccgttgcca tggaagggaa 8041 agtgataaaa ccactacatg taaaaggaac cattgaccac ccggccctag cgaaacttaa 8101 attcactaaa tcttcttctt acgacatgga gtttgctaaa ctaccgaccg aaatgaaaag 8161 cgacgcattc gggtatacaa cggaacaccc cgaagtattt tacaactggc atcacggagc 8221 tgtccaattt tccggcggaa ggttcaccat ccctacagga gtcggaggcc ccggagatag 8281 cggaaggcct atactggata actccggaaa agtggtagcc atagtcctag gaggagctaa 8341 tgaagtgcca ggaacggcac tttctgttgt cacctggaat aagaagggag ccgctattaa 8401 aaccacccac gaagatactg tagagtggtc gcgggctatt accgctatgt gcatcctgca 8461 gaacgtcaca ttcccatgtg accgaccgcc aacttgctat aatcgtaatc ctgacttgac 8521 cctaaccatg ttggaaacaa atgtcaatca cccttcgtac gacgttctgc tggacgctgc 8581 tctgaggtgc cccacgagac ggcacgtcag atcaacgccc accgatgact tcactctcac 8641 agcaccgtac ctcggcttgt gtcacagatg taagacgatg gaaccatgct acagccctat 8701 aaaaatcgaa aaagtgtggg atgatgccga tgacggagtt ctccgtatac aagtaagtgc 8761 ccagttaggg tacaacaggg cgggcactgc agctagcgcc cgactccggt tcatgggcgg 8821 aggagtgcct ccggaaatcc aggagggagc aattgcagat tttaaggtct tcacgtccaa 8881 accatgttta cacctatcac ataaaggata ctttgtcatt gtcaagtgcc ctcctggtga 8941 tagtattaca acatcattga aagtgcatgg ctcggatcaa acctgcacaa ttccaatgcg 9001 agtaggttac aagttcgtag gcagggaaaa atatactctg ccaccaatgc atgggacaca 9061 aataccttgc cttacctacg aaaggacacg agagaaaagt gcaggatacg tgaccatgca 9121 tcgtcccgga caacaatcca taaccatgct gatggaagag agcggagggg aggtgtacgt 9181 acaaccgacc agtgggcgaa acgtcaccta cgagtgtaaa tgcggagact ttaaaactgg 9241 gactgtcact gcgcgcacta aaatagacgg ctgtacagaa aggaaacaat gcattgcgat 9301 ttctgccgac cacgtcaaat gggtgtttaa ctcccctgac ttgatcaggc ataccgacca 9361 cacagcccaa gggaagttgc atataccatt cccgctacag caggctcaat gtacagtacc 9421 actggcgcac cttccaggcg ttaagcatgc ttatcgcagt atgtctctga cactgcacgc 9481 tgagcatcct acattgctta ctacccgcca tcttggagaa aatcctcagc ccactgcaga 9541 atggattgtc gggagtgtaa ctcgaaactt ctccataacc atacaagggt tcgagtatac 9601 ttggggaaat cagaaaccgg tccgagtgta cgcgcaggaa tcggcacctg gcaatcctca 9661 tggctggcca catgaaatcg tacgccatta ctaccacctc tatcccttct acaccgttac 9721 agtgctgagc ggcatgggac tggccatatg cgctggctta gtgatcagta ttttatgctg 9781 ctgcaaagca agaagggatt gcctaacacc ttaccaactg gccccgaacg ctaccgtacc 9841 atttctggta acattgtgtt gctgtttcca acggacttca gcggatgaat ttaccgatac 9901 catggggtac ctatggcaac acagtcaaac aatgttctgg atacaattgg tcataccttt 9961 agcagcagtg ataactttgg ttagatgttg ctcctgctgt ctaccttttt tattggttgc 10021 cagtcctcct aacaaagcgg acgcctacga acatacgatc actgtcccaa atgcgccgtt 10081 gaactcgtat aaagcactag tggaacggcc tgggtatgcc cccttgaatc ttgaagtcat 10141 ggtcatgaac acccagatca taccatcggt taaacgtgaa tacattacct gcaggtacca 10201 caccgttgtt ccttcaccgc agattaaatg ttgcggaact gtcgaatgcc cgaaaggtga 10261 aaaagcagac tatacctgca aggtgttcac tggtgtgtac ccatttctgt ggggaggagc 10321 acagtgtttt tgcgactccg aaaacagtca gcttagcgac aagtacgtcg aactgtcaac 10381 agattgcgcc acagaccatg ccgaggcggt cagagtacac acggcttcgg tgaaatcaca 10441 gctccgaata acctacggga actccacagc acaagtagac gtatttgtca acggtgtgac 10501 tccagccagg agcaaagaca tgaaattgat agccggccca ttatctacta cattttcccc 10561 gtttgataat aaggtcatta tatatcatgg gaaagtctat aactatgact tcccggaatt 10621 tggggccgga acacctggag ctttcggaga tgtccaagcg tcatccacca ccggatcaga 10681 tctattagca aacacagcaa ttcatttgca gaggccggaa gccagaaaca tacacgtccc 10741 gtacacccaa gctccaagcg ggttcgaatt ctggaagaat aacagcggtc agcctttatc 10801 tgacactgcc cctttcggat gcaaagtcaa tgtcaacccg ctacgtgcag acaagtgtgc 10861 cgtgggatca ctcccgatat ccgtggatat accggacgct gcatttacac gcgtatccga 10921 gcccctgcca tcactgctta agtgcaccgt tactagttgc acatactcta cagactatgg 10981 cggagtgctc gtgttgacat acgagtcgga tcgcgcgggg caatgcgctg tacactcgca 11041 ttcatcaaca gcggtactgc gagacccatc ggtatacgtc gagcaaaaag gggagactac 11101 acttaaattt agtacgcgtt ccttgcaggc agacttcgag gtatcgatgt gcggaacgag 11161 aaccacttgc catgcccaat gtcaaccacc aacggaacac gtaatgaaca gaccccagaa 11221 gtcgactcca gacttctcct cagcgatatc caaaacatca tggaactgga ttacagcgct 11281 tatgggggga atttccagta tagctgctat agccgcaatt gtgctggtca tagcattagt 11341 atttacagca caacacagat gaatacaaac ttattacatt acgtatgtat tcgatgttat 11401 atgtataaca atgaacgtaa actcgatgta cttccgagga tgtgggtgca taatgccata 11461 cagcggtcca cttatcatga tatagtttta tagttaccac cggtgaaact cgatgtattt 11521 ccgaggaagt gtggtgcata atgccacaca ccggttgaat ttaatagttt tagtcaagac 11581 tgagaaaact cgatgtactt ccgaggatgt ggtgcataat gtcacacatc agtcttatca 11641 tattagttca aaggcaatat tacccctgaa tagtaacaaa actagaaaat cgtcaaccac 11701 cacggatacc gggatcggtg tcctactacg gtagttgaaa ataactttat agaattttaa 11761 aattttcttt attaaaatct tttgtttttc ttttattatt tcaaaatttt gtttttaata 11821 tttc //